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This animated half hour program is based on the popular pre-school book series by British author Lucy Cousins. Maisy is a young mouse who explores her world and learns about growing up. She is friendly, good-natured and independent, but also a little naive. Along with her animal friends, Maisy enjoys simple adventures like going to a farm or sailing a boat or making music. Every day the friends try new things and make new discoveries.

Maisy's imaginative tales support viewers' comprehension of story structure and their appreciation of language, promoting early literacy. Maisy's adventures offer models of creative problem solving, as well as an ethical spirit and an optimistic, even-keeled emotional tone that support preschoolers' own adventures in the real world. In addition, Noggin has produced a interstitial segment in which Maisy explores the alphabet.